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Decoding the biosynthetic pathway of the anticancer alkaloid piperlongumine in Piperaceae plants
Piperaceae plants have been traditionally used to alleviate cancer-like symptoms.1 Piperlongumine is a major bioactive alkaloid produced by Piper species, which demonstrated selective in vitro and in vivo cytotoxicity against various human cancer cell lines by triggering apoptotic and autophagic cell death